Clarkson Chemistry PhD student Jared Morse will present Chloride as a Dynamic Mediator of the cGAS-STING Pathway
Among the innate immune system, activation of the cGAS-STING (cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING)) signaling pathway is one of the primary defense responses to cytosolic DNA. Which could be a result of nuclear DNA damage, microbial infection, and cellular stress among others. Chloride, being the most plentiful anion found throughout cellular physiology, is needed for many cellular processes. Interestingly, very little is known about any role the chloride ion plays in regulating this innate immune pathway. Therefore, the specific relationship between cGAS-STING and cellular chloride is yet to be completely understood. Thus, the goal of this study is to functionally investigate this relationship via dysregulation of whole cell chloride homeostasis. By employing various non-selective chloride channel blockers to dysregulate cellular chloride, we hope to begin to navigate the role chloride plays in the cGAS-STING signaling axis.
Friday, September 1, 2023
3:30 PM
BH Snell Hall 214, Potsdam Campus
Zoom Information: Link
Meeting ID: 950 1099 7564 Passcode: chemistry
