Kashif Ijaz Ph.D. Student from Clarkson University in the department of Materials Science and Engineering Program will present on Biomaterials for Bone Regeneration: Bridging Conventional Therapies with Synthetic 3D Scaffolds
Bone fractures represent a significant global public health challenge, with critical-size bone defects being one of the most severe complications. These defects are characterized by their inability to heal without intervention and need surgical intervention to restore. To address these challenges, over 2 million bone grafting procedures are performed worldwide annually. Traditional bone grafting approaches, including autografts, allografts, metallic implants, and synthetic grafts, have been widely utilized. However, each method presents limitations such as donor site morbidity, immune rejection, and inadequate mechanical properties highlighting the need for an ideal biomaterial. Hydroxyapatite (HA), a calcium phosphate-based bioceramic, is the primary mineral component of natural bone and has been extensively investigated due to its excellent biocompatibility and osteoconductivity. Despite these advantages, HA lacks intrinsic antibacterial properties and exhibits poor mechanical strength, particularly in load-bearing applications, limiting its potential as a standalone bone graft material. Cerium (Ce) doping has emerged as a promising strategy to enhance antibacterial functionality. This research focuses – for the first time – on the synthesis of cerium-doped hydroxyapatite (CeHA) using a flow system. This study also aims to develop a next-generation 3D porous scaffold by integrating CeHA with alginate and gelatin natural polymers, with enhanced mechanical strength, bioactivity, and antibacterial functionality through freeze drying process. The proposed biomaterial holds significant potential for effective bone regeneration and defect repair, addressing the existing limitations of conventional bone grafting techniques.
Friday, February 7th, 2025, 3:30 PM, BH Snell 214Potsdam Campus
Zoom Information: Link
Meeting ID: 950 1099 7564
Passcode: chemistry