Edmond Palermo PhD. Associate Professor at Materials Science and Engineering at Rensselaer Polytechnic Institute will speak on Polyermized pro-drug as locally implantable depots with vastly extended timescales of release.
Abstract: Our lab is focused on converting drugs into polymerizable pro-drugs, which we then convert to high polymer. We further process such polyprodrugs into various materials including electrospun fibers, microparticles, thin films, and two-photon printed microneedles. Two example cases are estradiol (E2) and curcumin, which we have converted into polyesters with controllable degradation/release rates and thermomechanical properties. Both have shown promise in the context of chronic injury conditions which require long term local release of bioactive compounds. Polymerized curcumins, for example, are shown to significantly downregulate inflammatory markers, enhance white matter sparing, and improve functional motor recovery following contusive spinal cord injury in mice.
Starts at 3:30 PM, BH Snell Hall 214
Zoom: Link
Meeting ID: 997 6264 6290
Passcode: chemistry