Prof. Kaiyu Fu from University of Notre Dame in the Department of Chemistry and Biochemistry will present on Engineering and understanding nano-bio interfaces of electrochemical biosensors for real-time monitoring
Abstract: The emerging biosensing devices broadly extend our capability to measure and monitor the biomolecules in living organisms. Electrochemical biosensors based on structure‐switching aptamers offer many advantages because they can operate directly in complex samples. They hold the exciting potential to integrate molecular detection with signal processing and wireless communication in a miniaturized, low‐cost system. However, as electrochemical biosensors are miniaturized to the micrometer scale, their signal‐to‐noise ratio degrades and reduces their utility for molecular diagnostics. In this talk, I will first present a novel electrochemical detection platform that consists of highly nanoporous electrodes for ultrasensitive biomolecule detection. I will explore how electron transfer and ion transport are coupled in the nanostructures for the mass-limited samples. Next, I will present a real-time sensing technology to measure molecules in live animals through nanoporous electrodes with surface-immobilized aptamers. This electrochemical-based aptamer biosensor can continuously read the target molecule’s concentration profile and reaction kinetics. As an example, I will show an implantable biomedical device based on this biosensing technology to collect tissue-based pharmacokinetics and measure the concentrations of the chemotherapy drug at multiple tumor sites in a rodent model. Last, I will introduce a recent study that tailors electrode surface charge to discriminate and quantify chemically similar drugs and their metabolites. Ideally, this strategy will revolutionize drug molecule tracking to elucidate the difference in metabolic pathways in living organisms. Overall, this talk depicts a generalized approach to accessing in vivo real-time biochemical information for future clinical applications.
Biography: Kaiyu Fu is an Assistant Professor of Chemistry and Biochemistry at the University of Notre Dame, USA. He has co-authored more than 30 papers, one book chapter and one US patent. He is a recipient of the ACS Division of Analytical Chemistry Graduate Fellowship. He received his B.E. (2011) and M.S. (2014) in polymer science and engineering from Sichuan University and Fudan University, respectively. He then received his Ph.D. (2018) in analytical chemistry from Notre Dame, followed by postdoctoral training at the School of Engineering and School of Medicine at Stanford University until 2022. He currently has broad interests in electrochemical biosensors, polymeric materials, nanoscience, and microfabrication.
Friday, November 15th, 2024, 3:30 PM, BH Snell Hall 214Potsdam Campus
**The seminar will only be on site this week.**