Aneeta Arshad from Clarkson University of the Chemistry and Biochemistry Department will present on Proteomic Analysis of Breast Milk for Early Detection of Breast Cancer: A Mass Spectrometry Approach
Abstract: Breast cancer (BC) remains one of the leading causes of cancer-related mortality worldwide, with early detection being critical to improving patient outcomes. However, current screening methods, such as mammography, often fail to detect tumors at the earliest stages or may lead to false positives. Mass spectrometry provides a high-throughput, highly sensitive platform to analyze the proteome of biological samples such as blood, serum, or tissue, enabling the identification of subtle changes in protein expression and post-translational modifications associated with tumorigenesis. The identification of reliable protein biomarkers offers a promising avenue for the development of more precise, minimally invasive diagnostic tools. This seminar focuses on the application of mass spectrometry-based proteomics to discover and validate potential protein biomarkers for the early detection of BC. The biological material used for analysis was milk samples from donors with BC and matched controls. Preliminary studies have identified several candidate proteins that are dysregulated in BC, compared with controls. Some of these proteins are involved in cell signaling, immune modulation, and metabolic pathways. These findings show that protein biomarkers can play a key role in the early detection of BC.
Friday, January 31, 2025, 3:30 PM, SH Snell Hall 214 Potsdam Campus
Zoom Information: Link
Meeting ID: 950 1099 7564
Passcode: chemistry