Daniel Massana Roquero
Department of Chemistry & Biomolecular Science
Clarkson University
will speak on
“Interpenetrating Responsive Polymer Networks in Alginate Hydrogels for “Smart” Drug Delivery”
Abstract:
The development of more effective therapeutics has been enhanced by the use of drug delivery systems. These materials i) allow targeted delivery of drugs; ii) prevent drug degradation and iii) avoid undesired immune responses. Calcium alginate hydrogels are well stablished materials in drug (e.g. proteins, growth factors, DNA) delivery applications. However, when it comes to targeted drug delivery, the high porosity of the material plays a negative role. The entrapped (bio)molecules are subject to fast diffusion out from the hydrogel providing an uncontrolled release profile. For targeted and smart delivery of drugs we have developed a porosity control strategy based on the interpenetration of polyvinyl alcohol-diboronate network (IPN) within calcium alginate hydrogels. The IPN efficiently closes the hydrogel pores decreasing leaching rates of proteins by 20-30-fold. In addition the hydrolytic degradation of boronate esters in the presence of biologically relevant concentrations of hydrogen peroxide (H2O2) was exploited for the design of a responsive composite hydrogel. Hydrogen peroxide, in bulk solution or catalytically produced in situ by oxidases enzymes, degraded the IPN reopening the original pores of the hydrogel and allowing the release of entrapped proteins. The signal-triggered release was suitable in the presence of different substances (e.g. glucose, lactate or hypoxanthine) that are biomarkers of certain physiological disorders.
Friday, April 2, 2021
3:30 pm
https://clarkson.zoom.us/j/97229541614?pwd=alp2c0pzUDVTWkVkQVEwTjVTT0k5UT09
Meeting ID: 972 2954 1614
Passcode: 048492
